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Otelixizumab another disappointment in type 1 diabetes

Date March 14, 2011

Strike two against an antibody approach to treating type 1 diabetes. Otelixizumab, the protein GlaxoSmithKline and Tolerx were testing in phase III, failed to improve symptoms in recently diagnosed patients with the autoimmune form of the disease.

The failure was not judged as a surprise by some industry observers as a related molecule, teplizumab, failed for Eli Lilly and MacroGenics in October 2010. However, it is certainly a disappointment in terms of advancing new treatments for this disease - the product is one of just three late-stage candidates for type 1 that does not rely on insulin replacement.

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