Strike two against an antibody approach to treating type 1 diabetes. Otelixizumab, the protein GlaxoSmithKline and Tolerx were testing in phase III, failed to improve symptoms in recently diagnosed patients with the autoimmune form of the disease.The failure was not judged as a surprise by some industry observers as a related molecule, teplizumab, failed for Eli Lilly and MacroGenics in October 2010. However, it is certainly a disappointment in terms of advancing new treatments for this disease - the product is one of just three late-stage candidates for type 1 that does not rely on insulin replacement.
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