Print

Therapeutic focus – ALS field entering pivotal stage

Date August 02, 2010

The past few months have seen a sudden flurry of activity within the niche but major unmet medical field that is amyotrophic lateral sclerosis (ALS) – last month Actelion paid €10m for an option to acquire the private French group, Trophos, should olesoxime prove successful in a phase III ALS trial which will read out next year; while in May Teva’s ALS candidate, talampanel, failed a phase II study.

The only FDA-approved drug for ALS, riluzole, offers a modest increase in average survival time. Similar to many neurodegenerative disorders, a genuine disease-modifying therapeutic agent is desperately needed for patients with ALS, estimated to affect 50,000 people worldwide. Actelion’s move on Trophos and Teva’s setback throws the spotlight on a rather thin-looking late stage pipeline of ALS candidates, although the next 18 months could yet bring some much needed success stories (see tables below).

This content is written, edited and published by EP Vantage and is distributed by Evaluate Ltd. All queries regarding the content should be directed to: news@epvantage.com

EP Vantage is a unique, forward-looking, news analysis service tailored to the needs of pharma and finance professionals. EP Vantage focuses on the events that will define the future of companies, products and therapy areas, with detailed financial analysis of events in real-time, including regulatory decisions, product approvals, licensing deals, patent decisions, M&A.

Drawing on Evaluate, an industry-leading database of actual and forecast product sales and financials, EP Vantage gives readers the insight to make value-enhancing decisions.

EP Vantage SM ©2014 EP Vantage Ltd